During the scene of 2008 Mumbai attacks, an estimated number of 80 tweets were sent by the eyewitnesses in every 5 seconds. The users of Twitter on the ground helped to compile a list of the injured and dead. In addition, the users sent out important information regarding the location of nearest hospitals and nursing homes emergency phone numbers needing blood donations.

Foreign Affairs Ministry of Israel David Saranga had  announced on December 30, 2008, that the government of Israel would be first to organize a world wide press conference through Twitter to take the questions from the general  public about the point of war against the Hamas, in Gaza.

In January 2009, an US Airways Flight1549 came across with multiple strikes of bird and was forced to ditch in Hudson River. A passenger name Janis Krums, on one of the ferries rushed there for the immediate help and he took some pictures of the downing plane while evacuating the passengers and sends them to the Twittpic for the further assistance. It was all before the arriving of any other media personals at that scene of panic.

The Country Fire Authority of Australia took the help of Twitter to send out instant updates and alerts regarding the Victorian bushfires in February 2009.During this time   Kevin Rudd, the Prime Minister of Australia, also used his account of the Twitter   to send out vital information during that scene of the fires about the various assistance like donation of the blood and the money and contacts for the emergency help as a part of the rescue operation.

The first and the foremost criminal prosecution evolving from Twitter posts started in April 2009. The convict Daniel Knight Hayden was arrested by the FBI agents, supporting the protest of the Tea Party against the Barack Obama’s policies.  Allegedly Hayden was sending threatening tweets of violence in connection with his aim to attend that protest in the Oklahoma City, Oklahoma.

The first time Twitter was exposed to the space when Michael J. Massimino, the astronaut in May 2009, used it to send vital updates of repair mission of Hubble Space Telescope. In that same month Brillstein-Grey and Reveille Production Entertainment made an announcement that they would soon produce a television series in which Twitter will be used to track down the famous and the celebrities.

In May 2009, the notable Webby Award “Break out of the Year” was presented to the team of Twitter. Fraud allegations during the Iranian presidential election, in June 2009, protesters used the favors of Twitter as mode of communication to the outer world and as a rallying tool, after the administrative body banned several other systems of communication.

In July 2009, a Chicago based real estate management associates, Horizon Realty Group sued Amanda Bonnen, one of its former tenant for libel based for a Twitter message sent to his friends. Horizon Realty contends that Bonnen defamed the company by making a posting of tweets against their sole interest and the privacy.